MEK Inhibitor, CAS 334951-92-7

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: (3Z)-3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-6-carboxamide

Purity: ≥95%

Formula Markup: C26H26N4O2

Formula Weight: 426.52

CAS Number: 334951-92-7

Notes: A MEK5 inhibitor (IC50 = 1.5 nM); selective for MEK5 over ERK5, ALK5, MEK1, and MEK2 (IC50s = 59, 580, >6,300, and >6,300 nM, respectively) and a panel of 79 other kinases at 10 µM; decreases the levels of phosphorylated ERK5 in sorbitol-stimulated HeLa cells at 1, 3, or 10 µM; inhibits TGF-β1-induced increases in N-cadherin levels, decreases in E-cadherin levels, and cell migration in a scratch assay in A549 cells at 10 µM; decreases the number of lung nodules in a A549 mouse model of lung metastasis at 20 mg/kg per day

• SKU: CAY43190-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 43190-1
• Package Unit: 1 mg
• Quantity Unit: STK