Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 5-(3,4-dichlorophenyl)-6-methyl-2,4-pyrimidinediamine
Purity: ≥98%
Formula Markup: C11H10Cl2N4
Formula Weight: 269.129
CAS Number: 7761-45-7
Notes: An HNMT inhibitor (IC50 = 91 nM); inhibits Dhfr (IC50s = 1, 1.6, and 60 µM for the chicken, rat, and T. equiperdum enzymes, respectively); increases the levels of histamine in mouse cerebral cortex, diencephalon, midbrain, and pons medulla at 10 mg/kg; decreases the duration of tonic and clonic convulsions in a mouse model of electroshock-induced seizures at 5 or 10 mg/kg; inhibits scopolamine-induced learning deficits in the passive avoidance test in mice at 2 or 5 mg/kg