Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3-oxo-olean-18-en-28-oic acid
Purity: ≥98%
Formula Markup: C30H46O3
Formula Weight: 454.7
CAS Number: 6713-27-5
Notes: Moronic acid is a triterpenoid that has been found in M. euosma and has diverse biological activities.{49918,49919,49920,49921} It inhibits α-glucosidase and α-amylase (IC50s = 10.57 and 20.08 µg/ml, respectively).{49918} Moronic acid inhibits the replication of HIV-1 in H9 T cells (EC50 = 23250).{49920} Moronic acid inhibits ear edema induced by the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA; Item No. 10008014) in mice (ID50 = 379 nmol/ear). It also reduces the number of tumors per mouse and the percentage of mice with tumors in a two-stage mouse skin model of tumor formation initiated and promoted by the polycyclic aromatic hydrocarbon (PAH) 7,12-dimethylbenz[a]anthracene (DMBA; Item No. 30383) and TPA, respectively.{49921}
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