Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-6-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Purity: ≥98%
Formula Markup: C17H15F3N4
Formula Weight: 332.3
CAS Number: 2499962-58-0
Notes: MTK 458 is a PTEN-inducible putative kinase 1 (PINK1) activator.{72449} It, in combination with the mitochondria uncoupler FCCP (Item No. 15218), increases levels of PINK1 and phosphorylated ubiquitin (pUb) in HeLa cervical cancer cells when used at a concentration of 6.6 µM. MTK 458, in combination with FCCP, induces mitophagy in HeLa cells (EC50 = 0.44 µM). It inhibits doxycycline-induced increases in the mitochondrial levels of insoluble ornithine transcarbamylase (OTC) in HeLa cells when used at concentrations of 25 or 50 µM. In vivo, MTK 458 (50 mg/kg per day) decreases the midbrain levels of total α-synuclein and insoluble α-synuclein aggregates in a mouse model of Parkinson's disease induced by α-synuclein injection in the ipsilateral striatum.
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