Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (3R,4S)-rel-4-(1,3-benzodioxol-5-yl)-3-(4-fluorophenyl)-1-[1-(1H-1,2,4-triazol-1-ylcarbonyl)-4-piperidinyl]-2-azetidinone
Purity: ≥98%
Formula Markup: C24H22FN5O4
Formula Weight: 463.469403
CAS Number: 1881244-28-5
Notes: A MAGL inhibitor (IC50s = 0.25 and 7.4 nM for the rat and human enzymes, respectively); selective for MAGL over FAAH (IC50 = 2,880 nM for the human enzyme) and CB1 and CB2 receptors (IC50s = >10,000 nM for both); decreases disease severity in a mouse model of MOG (35-55)-induced EAE at 3 mg/kg, an effect that can be reversed by AM251 or AM630; induces analgesia in the formalin test in mice at 0.3 mg/kg; inhibits LPS-induced motor and cognitive impairments in the rotarod and passive avoidance tests, respectively, and LPS-induced depressive-like behavior in the forced swim test, in mice at 3 mg/kg; increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity, in a rat model of predator stress-induced anxiety using TMT
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