Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 1-[3-(9H-carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinol, monohydrochloride
Purity: ≥98%
Formula Markup: C27H30N2O2 / HCl
Formula Weight: 451.00002
CAS Number: 184845-18-9
Notes: A BGT1 antagonist (IC50 = 5.1 µM for the human transporter); inhibits mouse GAT1, mouse GAT2, mouse GAT3, rat SERT, rat NET, and rat DAT (IC50s = 29.62, 45.29, 22.51, 5.29, 7.91, and 4.08 µM, respectively, in CHO cells expressing the mouse or rat transporters); increases the latency to paw withdrawal in a mouse model of partial sciatic nerve ligation-induced allodynia when administered intravenously at 0.01 or 0.03 mg/kg; decreases immobility time in the forced swim test in mice at 2 mg/kg; inhibits sound-induced clonic and tonic seizures and maximal electroshock-induced seizures in mice (ED50s = 26, 19, and 73 µmol/kg, respectively).
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