NVS-MLLT-1, CAS 2561471-13-2

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N-[2-[[(2S)-2-methyl-1-pyrrolidinyl]methyl]-1H-benzimidazol-6-yl]-6-isoquinolinecarboxamide

Purity: ≥98%

Formula Markup: C23H23N5O

Formula Weight: 385.5

CAS Number: 2561471-13-2

Notes: NVS-MLLT-1 is an inhibitor of the YEATS domain-containing proteins MLLT1 and MLLT3 (IC50s = 0.15 and 0.254 µM, respectively).{67849} It is selective for MLLT1 and MLLT3 over the YEATS domain-containing proteins YEATS2 and YEATS4 (IC50s = >20 µM for both), as well as over the cat eye syndrome critical region protein 2 (CECR2) bromodomain (IC50 = >40 µM). NVS-MLLT-1 binds to wild-type MLLT1 (IC50 = 0.18 µM) and MLLT1 containing an in-frame insertion (T1 mutant) or deletion (T2 mutant) mutation (Kds = 0.24 and 0.22 µM, respectively).{67850} See the Structural Genomics Consortium (SGC) website for more information.

• SKU: CAY41318-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41318-10
• Package Unit: 10 mg
• Quantity Unit: STK