Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 1-cyclopropyl-1,4-dihydro-8-methyl-7-[5-methyl-6-(methylamino)-3-pyridinyl]-4-oxo-3-quinolinecarboxylic acid
Purity: ≥98%
Formula Markup: C21H21N3O3
Formula Weight: 363.4
CAS Number: 245765-41-7
Notes: Ozenoxacin is a quinolone antibiotic.{57959} It is active against clinical isolates of S. pyogenes, P aeruginosa, and P. acnes and clinical isolates of antibiotic-sensitive and -resistant S. aureus, S. epidermidis, and S. pneumoniae (MIC50s = 0.00625-1.56 mg/L). Ozenoxacin inhibits S. aureus DNA gyrase and topoisomerase IV (IC50s = 4.5 and 0.617 mg/L, respectively). It reduces insulin- or 5α-dihydroxy testosterone-induced triglyceride production and lipid droplet formation in primary hamster sebocytes when used at a concentration of 30 µM.{72524} Ozenoxacin (30 µg/ml) decreases heat-killed C. acnes-induced increases in IL-6 and IL-8 production in HEKa primary human keratinocytes and IL-1β, IL-6, IL-8, and TNF-α production in THP-1 monocytes.{72525} Topical application of ozenoxacin (1%) decreases skin lesion bacterial counts in a mouse model of burn infection caused by S. aureus.{57959} Formulations containing ozenoxacin have been used in the treatment of S. aureus- or S. pyogenes-associated impetigo.
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