PF-06821497, CAS 1844849-10-0

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 5,8-dichloro-2-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-3,4-dihydro-7-[(R)-methoxy-3-oxetanylmethyl]-1(2H)-isoquinolinone

Purity: ≥98%

Formula Markup: C22H24Cl2N2O5

Formula Weight: 467.34184

CAS Number: 1844849-10-0

Notes: An EZH2 inhibitor (Ki = i = 70 nM); reduces H3K27me3 in, and the proliferation of, Karpas-422 non-Hodgkin lymphoma cells (IC50s = 4 and 6 nM, respectively); induces tumor regression in a Karpas-422 mouse xenograft model at 100 mg/kg, s.c.

• SKU: CAY42500-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42500-5
• Package Unit: 5 mg
• Quantity Unit: STK