(R)-AS-1, CAS 2506367-95-7

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: aR-methyl-2,5-dioxo-N-(phenylmethyl)-1-pyrrolidineacetamide

Purity: ≥95%

Formula Markup: C14H16N2O3

Formula Weight: 260.3

CAS Number: 2506367-95-7

Notes: (R)-AS-1 is a positive allosteric modulator of excitatory amino acid transporter 2 (EAAT2; EC50 = 11 nM in a glutamate uptake assay).{66851} It is selective for EAAT2 over EAAT1, EAAT3, and a panel of 30 other ion channels, transporters, receptors, and enzymes. (R)-AS-1 (60 and 90 mg/kg) increases spontaneous locomotor activity in mice. It has anticonvulsant activity in mouse models of seizures induced by maximal electroshock (MES), pentylenetetrazole (PTZ; Item No. 18682), or electrical stimuli of 32 or 44 mA (ED50s = 66.3, 36.3, 15.6, and 41.6 mg/kg, respectively).

• SKU: CAY41673-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41673-25
• Package Unit: 25 mg
• Quantity Unit: STK