Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7S)-6,7,8,9-tetrahydro-7-(1-pyrrolidinyl)-5Hbenzocyclohepten-2-yl]-1H-1,2,4-triazole-3,5-diamine
Purity: ≥98%
Formula Markup: C30H34N8
Formula Weight: 506.6
CAS Number: 1037624-75-1
Notes: R428 is a small molecule inhibitor of Axl kinase, both in an in vitro biochemical assay and in a cell-based assay using phosphorylation of Ser473 on Akt as the readout (EC50s = 14 nM for both).{33459} It is orally bioavailable, blocks angiogenesis in corneal micropocket and tumor models, and reduces metastatic burden while extending survival in mouse models of breast cancer metastasis.{33459} R428 synergizes with cisplatin (Item No. 13119) to enhance suppression of liver micrometastasis.{33459} R428 is used to study the role of Axl kinase signaling in cancer, cellular senescence, and Zika virus infection.{33458,33460,33461}
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