Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 1-[2-[[[trans-3-fluoro-1-(3-fluoro-2-pyridinyl)cyclobutyl]methyl]amino]-5-pyrimidinyl]-1H-pyrrole-3-carboxamide
Purity: ≥95%
Formula Markup: C19H18F2N6O
Formula Weight: 384.382866
CAS Number: 1345410-31-2
Notes: Reldesemtiv is an activator of fast skeletal troponin.{69950} It increases ATPase activity in isolated rabbit psoas muscle myofibril preparations with a 40% activation concentration (AC40) value of 0.6 µM. Reldesemtiv is selective for fast skeletal troponin over cardiac and slow skeletal troponin.{69951} It is also selective for fast skeletal troponin over a panel of 79 enzymes, receptors, ion channels, and transporters at 100 µM.{69950} Reldesemtiv increases muscle tension in a skinned fast skeletal muscle fiber assay with a 30% muscle force (DF30) value of 0.8 µM.{69950} In vivo, reldesemtiv (10 mg/kg, p.o.) increases running time in the rotarod test, indicating increased exercise performance, in a rat model of heart failure-induced skeletal myopathy.{69951}
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