Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4-(6-methoxypyrazolo[1,5-b]pyridazin-3-yl)-N-[3-methoxy-5-(trifluoromethyl)phenyl]-2-pyrimidinamine
Purity: ≥98%
Formula Markup: C19H15F3N6O2
Formula Weight: 416.4
CAS Number: 748142-15-6
Notes: SGC-CLK-1 is an inhibitor of CDC-like kinase 1 (Clk1) and Clk2 (IC50s = 13 and 4 nM, respectively).{66848} It is selective for Clk1 and Clk2 over Clk3, Clk4, homeodomain-interacting protein kinase 1 (HIPK1), HIPK2, and serine/threonine kinase 16 (STK16; IC50s = 363, 46, 50, 42, and 49 nM, respectively). SGC-CLK-1 (1 µM) inhibits the proliferation of MDA-MB-435 breast cancer and U-118 MG glioma cells. It induces diffuse localization of Clk2 and phosphorylated serine/arginine-rich (pSR) proteins, targets of Clks, without reducing the levels of phosphorylated SR proteins in MDA-MB-435 and U-118 MG cells when used at a concentration of 500 nM. See the Structural Genomics Consortium (SGC) website for more information.
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