Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (3aa,5a,6aa)-hexahydro-N-(3-methoxy-1,2,4-thiadiazol-5-yl)-5-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-cyclopenta[c]pyrrole-2(1H)-carboxamide
Purity: ≥95%
Formula Markup: C18H22N8O2S
Formula Weight: 414.488
CAS Number: 1445987-21-2
Notes: A JAK inhibitor (IC50s = 0.1, 0.9, and 7.7 nM for JAK1, -2, and -3, respectively); selective for these kinases over TYK2 (IC50 = 42 nM); inhibits the activation, proliferation, and TGF-β-1-induced migration of HSC-T6 cells from 0.1-10 µM; decreases collagen production and JAK1 and STAT3 phosphorylation in HSC-T6 cells; decreases disease severity and paw swelling in a rat model of adjuvant-induced arthritis at 3 mg/kg; increases survival, white blood cell count, red blood cell count, and platelet count and decreases body weight loss and disease severity in a mouse model of bone marrow transplant-induced GVHD when administered prophylactically at 5 mg/kg
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