Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3,4-dihydro-6-[[[6-methoxy-4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-2(1H)-isoquinolinecarboxylic acid, phenyl ester
Purity: ≥98%
Formula Markup: C31H25F3N2O4
Formula Weight: 546.536489
CAS Number: 913541-47-6
Notes: An MTTP inhibitor (IC50 = 8 nM); selectively inhibits MTTP-mediated secretion of ApoB over ApoA1 in primary human hepatocytes (IC50s = 81 and >30,000 nM, respectively); reduces postprandial increases in serum triglyceride levels in rats (ED50 = 7 mg/kg); reduces serum triglyceride levels, weight gain, and total cholesterol levels in ApoE-/- mice fed a high-fat diet at 5.8 mg/kg per day