Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[3,5-bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide
Purity: ≥98%
Formula Markup: C14H5ClF9N3O
Formula Weight: 437.7
CAS Number: 154563-54-9
Notes: An inhibitor of NF-κB- and AP-1-mediated gene transcription; inhibits NF-κB- and AP-1-mediated transcription in a reporter assay using Jurkat T cells (IC50 = 0.05 µM for both) and decreases IL-2 and IL-8 levels in Jurkat T cells (IC50 = 0.03 µM for both); reduces eosinophil and T cell infiltration into BALF and reduces Ap-1 and phosphorylated Ap-1 levels in isolated lung tissue in an ovalbumin-sensitized rat model of asthma at 20 mg/kg per day for three days; prevents tumor-induced decreases in skeletal muscle, brown adipose tissue, spleen, kidney, and heart mass in a rat model of cachexia at 1 mg/kg per day; inhibits bleomycin-induced decreases in body weight, increases in wet-dry lung weight ratio, and increases in lung total protein, Mpo, elastase, collagen, and IL-1β levels in a mouse model of pulmonary fibrosis at 10 mg/kg per day
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