Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[5-(1,1-dimethylethyl)-1H-pyrazol-3-yl]-2-[(3R)-3-(1-methylethyl)-1-piperazinyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Purity: ≥98%
Formula Markup: C20H30N8
Formula Weight: 382.516
CAS Number: 2351882-11-4
Notes: A spastin inhibitor (IC50 = 99 nM for the human enzyme); selective for spastin over a panel of 64 kinases but does inhibit TrkA by 65% at 2 µM; increases the number of cells with intracellular bridges during cell division, indicating microtubule stabilization, in recombinant human M87e4 spastin-expressing HeLa cells at 10 µM; inhibits neurite outgrowth in primary mouse hippocampal neurons at 1 and 5 µM; increases spinal cord injury-induced motor impairments in mice but does not affect motor function in sham mice at 20 mg/kg, i.p.; delays spinal cord inflammation resolution in the same mice
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