STF-1084, CAS 2298390-71-1

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: P-[2-[1-(6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]ethyl]-phosphonic acid

Purity: ≥95%

Formula Markup: C17H24N3O5P

Formula Weight: 381.363441

CAS Number: 2298390-71-1

Notes: An ENPP1 inhibitor (apparent Ki = 0.11 µM); selective for ENPP1 over ENPP2 and ALP (apparent Kis = 5.5 and >100 µM, respectively) and a panel of 468 kinases at 1 µM; inhibits the extracellular degradation of cGAMP in ENPP1-overexpressing and cGAS-expressing 293T cells (IC50 = 0.340 µM); increases mRNA expression of the gene encoding IFN-β in CD14+ primary human PBMCs incubated with conditioned medium from ENPP1-overexpressing and cGAS-expressing 293T cells cultured with STF-1084; increases the percentage of tumor-associated CD11c+ cells among APCs in a 4T1 murine mammary cancer model in combination with ionizing radiation

• SKU: CAY30440-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 30440-5
• Package Unit: 5 mg
• Quantity Unit: STK