Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2-amino-4,5,6,7-tetrahydro-6-(phenylmethyl)-thieno[2,3-c]pyridine-3-carboxylic acid, ethyl ester, monohydrochloride
Purity: ≥98%
Formula Markup: C17H20N2O2S / HCl
Formula Weight: 352.877
CAS Number: 25913-34-2
Notes: A ferroptosis inhibitor; inhibits (1S,3R)-RSL3-induced ferroptosis induced in primary rat nucleus pulposus cells at 1.25 or 2.5 µM; scavenges DPPH radicals in a cell-free assay in a concentration-dependent manner; inhibits Sod and catalase activities in primary rat liver microsomes at 10 and 250 µg/ml, respectively; inhibits carbon tetrachloride-induced increases in hepatic levels of Cyp450 and G6pc, serum levels of ALT and AST, and hepatic necrosis in a mouse model of liver damage at 100 mg/kg; inhibits puncture-induced increases in disc malformation and decreases in disc height in a rat model of IVDD; increases IVD cell levels of collagen II, Gpx4, and Nrf2 and reduces IVD cell levels of Mmp-13 in the same model
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