TL02-59, CAS 1315330-17-6

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 3-[(6,7-dimethoxy-4-quinazolinyl)oxy]-N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-benzamide

Purity: ≥95%

Formula Markup: C32H34F3N5O4

Formula Weight: 609.6

CAS Number: 1315330-17-6

Notes: An Fgr inhibitor (IC50 = 0.03 nM); selective for Fgr over LYN, Syk, and HCK (IC50s = 0.1, 470, and 160 nM, respectively), as well as Fes, FLT3, p38α MAPK, and TAOK3 (IC50s = 290, 633, 126, and 509 nM, respectively); selectively inhibits the growth of MV4-11 and MOLM-14 cells (IC50s = 0.78 and 6.6 nM, respectively) over THP-1 cells (IC50 = >3,000 nM); decreases the percentage of engrafted CD45+/CD33+ MV4-11 cells in the bone marrow and spleen in a mouse xenograft model 10 mg/kg; reduces radiation-induced pulmonary fibrosis in mice at 10 mg/kg

• SKU: CAY42729-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42729-5
• Package Unit: 5 mg
• Quantity Unit: STK