TPX-0046, CAS 2359650-19-2

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: (3aS,11R,20aR)-7-fluoro-2,3,3a,12,13,20a-hexahydro-11-methyl-17,19-metheno-1H,5H-cyclopent[5,6][1,4]oxazino[3,4-i]pyrazolo[4,3-f]pyrido[3,2-l][1,4,8,10]oxatriazacyclotridecin-14(11H)-one

Purity: ≥98%

Formula Markup: C21H21FN6O3

Formula Weight: 424.4

CAS Number: 2359650-19-2

Notes: A RET inhibitor (IC50 = 0.26 nM for the wild-type enzyme); selective for RET over a panel of 217 additional kinases but does inhibit 39 tyrosine kinases by > 50% at 26 nM; inhibits the phosphorylation of wild-type RET (IC50 = 21.9 nM) and 15 RET mutants (IC50s = 2.69-108 nM) in Ba/F3 cells

• SKU: CAY41990-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41990-10
• Package Unit: 10 mg
• Quantity Unit: STK