Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3-[[3-[(4-chlorophenyl)methyl]-3,5,7,8-tetrahydro-4-oxopyrido[4,3-d]pyrimidin-6(4H)-yl]methyl]-benzonitrile
Purity: ≥98%
Formula Markup: C22H19ClN4O
Formula Weight: 390.86532
CAS Number: 2485052-87-5
Notes: A ClpP activator (EC50 = 140 nM); reduces the proliferation of MDA-MB-231 and SUM159 cells (IC50 = 23 and 12 nM, respectively); decreases the levels of EF-Tu, TFAM, IDH, Hsp60, and mitochondrial complex II in a ClpP-dependent manner in MDA-MB-231 and SUM159 cells at 10 or 100 nM; reduces oxygen consumption rate, basal mitochondrial respiration, ATP production-linked oxygen consumption, maximal respiration, spare respiratory capacity, and extracellular acidification in a ClpP-dependent manner in MDA-MB-231 cells at 50 nM; decreases tumor volume in an MDA-MB-231 mouse xenograft model
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