Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3-(3-hydroxyphenyl)-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino]-1,6-naphthyridin-2(1H)-one
Purity: ≥95%
Formula Markup: C26H27N5O2
Formula Weight: 441.52508
CAS Number: 2540881-21-6
Notes: A RIPK3 inhibitor (IC50 = 0.02 µM); selective for RIPK3 over a panel of 50 receptors and enzymes at 1 µM and a panel of 77 kinases at 0.5 µM but does inhibit RIPK1 (IC50 = 0.024 µM) and 13 other kinases by > 90% at 0.5 µM; inhibits LPS-induced necroptosis in RAW 264.7 macrophages and isolated mouse BMDMs (IC50s = 17 and 22 nM, respectively) and TNF-α-induced necroptosis in recombinant human RIPK3-expressing HeLa cells, FADD-/- Jurkat cells, and U937 cells (IC50s = 722, 205, and 329 nM, respectively); increases survival, decreases lung injury and immune cell BALF infiltration, and inhibits decreases in arterial oxygen saturation in a mouse model of severe influenza A infection at 30 mg/kg
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