Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3-[1,1'-biphenyl]-4-yl-2,1-benzisoxazole-5-carboxylic acid
Purity: ≥98%
Formula Markup: C20H13NO3
Formula Weight: 315.3
CAS Number: 2922283-43-8
Notes: UNC7467 is an inhibitor of inositol hexakisphosphate kinase 1 (IP6K1) and IP6K2 (IC50s = 8.9 and 4.9 nM, respectively).{51871} It is selective for IP6K1 and IP6K2 over IP6K3 and inositol-triphosphate 3-kinase A (ITPKA; IC50s = 1,320 and 832 nM, respectively), as well as a panel of 30 other kinases at 1 µM, but does inhibit inositol phosphate multi-kinase (IPMK; IC50 = 24.4 nM). In vivo, UNC7467 (5 mg/kg per day) reduces body weight, fat mass, epididymal- and inguinal-adipose tissue deposit weights, and liver weight, as well as blood glucose levels in a pyruvate tolerance test after four weeks, in a mouse model of diet-induced obesity.
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