VU6005649, CAS 2137047-43-7

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine

Purity: ≥98%

Formula Markup: C16H12F5N3O

Formula Weight: 357.284016

CAS Number: 2137047-43-7

Notes: A positive allosteric modulator of mGluR7 and mGluR8; enhances L-AP4-induced calcium mobilization in HEK cells expressing mGluR7 or mGluR8 (EC50s = 0.65 and 2.6 µM, respectively); selective for mGluR7 and mGluR8 over mGluR1-6, as well as a panel of 67 GPCRs, ion channels, transports, and nuclear hormone receptors, at 10 µM but does inhibit the NK1 receptor (IC50 = 3.4 µM); increases the length of freezing time induced by contextual fear conditioning in mice at 50 mg/kg, i.p

• SKU: CAY43138-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 43138-50
• Package Unit: 50 mg
• Quantity Unit: STK