Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 5-nitro-N-[4-[7-(1,2,3,6-tetrahydro-4-pyridinyl)imidazo[1,2-a]pyridin-3-yl]phenyl]-2-furancarboxamide
Purity: ≥98%
Formula Markup: C23H19N5O4
Formula Weight: 429.436
CAS Number: 2740522-79-4
Notes: A STAT3 inhibitor; selectively inhibits the phosphorylation of STAT3 over STAT1, STAT5, JAK2, and Akt in AGS cells at 3 µM; binds to STAT3 in a cell-free assay (Kd = 7.55 µM) and increases the thermal stability of STAT3 in CETSA using AGS cells at 1 µM; inhibits STAT3 dimerization, nuclear accumulation, and transcriptional activation in cell-based assays; induces cell death in AGS cells at 3 µM, which can be reversed by Z-VAD-FMK, ferrostatin-1, liproxstatin-1, DFO, necrosulfonamide, or bafilomycin A1; decreases tumor volume and weight in 5-fluorouracil-sensitive and -resistant MGC803 gastric cancer mouse xenograft models at 10 mg/kg
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