Shelf life (days): 1460.0
Formulation: A solid
Formal Name: [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[4-(1-methylethyl)-1-piperazinyl]phenyl]-methanone
Purity: ≥98%
Formula Markup: C28H28N2O3S
Formula Weight: 472.5996
CAS Number: 849662-80-2
Notes: A selective estrogen receptor modulator; selectively binds to ERα over ERβ (Kis = 0.09 and 11.31 nM, respectively) and does not bind to the androgen, progesterone, glucocorticoid, or mineralocorticoid receptors; selectively inhibits estradiol-induced activation of ERα over ERβ in reporter assays using CV-1 cells (IC50s = 0.52 and 2.94 nM, respectively); binds to CB1 and CB2 receptors in CHO cells expressing the human receptors at 1 µM; reduces basal activity in CHO cells expressing human CB1 or CB2 receptors at 10 µM; activates AhR in a reporter assay using Hepa1 cells at 10 µM; inhibits estradiol-induced proliferation of MCF-7 and T47D breast cancer cells (IC50s = 3.95 and 41.1 nM, respectively); increases bone mineral density and uterine weight in ovariectomized mice
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