Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[(1S)-2-[[(1S)-3-fluoro-2-oxo-1-(phenylmethyl)propyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-carbamic acid, phenylmethyl ester
Purity: ≥95%
Formula Markup: C27H27FN2O4
Formula Weight: 462.5
CAS Number: 105608-85-3
Notes: Z-FF-FMK is an inhibitor of cathepsin B (Ki = 2.7 nM).{68823} It inhibits cell division, cell cycle progression, DNA replication, and chromosome decondensation in isolated T. niger fertilized embryos when used at a concentration of 100 µM.{68824} Z-FF-FMK (10 µM) prevents increases in cathepsin L activity induced by amyloid-β (1-40) (Aβ40), as well as prevents Aβ40-induced apoptosis, DNA fragmentation, and increases in cleaved poly(ADP-ribose) polymerase (PARP) levels, in primary rat cortical neurons.{68825} In vivo, Z-FF-FMK (5 nmol/animal) inhibits quinolinic acid-induced nuclear translocation of NF-κB, as well as inhibits quinolinic acid-induced increases in phosphorylated IκBα and IKKα levels, in the unilateral striatum in rats.{68826}
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