Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (2S)-2-[[(2S)-2-formyl-1-pyrrolidinyl]carbonyl]-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester
Purity: ≥98%
Formula Markup: C15H24N2O4
Formula Weight: 296.4
CAS Number: 86925-97-5
Notes: Z-Prolyl-prolinal (ZPP) is an inhibitor of prolyl endopeptidase (Kis = 0.35 and 0.5 nM for the mouse and human enzymes, respectively).{72521} ZPP (4 and 40 µM) inhibits the formation of angiotensin (1-7) from angiotensin II in kidney sections isolated from wild-type and Ace2-/- mice.{72522} In vivo, ZPP (10 and 50 mg/kg) reduces hippocampal neuronal cell death in a rat model of global ischemia.{72523}