Product Description: 7ACC1 (DEAC; Coumarin D 1421; D 1421) is a monocarboxylate transporter 1 (MCT-1)/MCT-4 specifc blocker. 7ACC1 attenuates renal cancer cell proliferation, migration, invasion and down-regulates the levels of MCT1/MCT4 expression and extracellular lactate. 7ACC1 is promising for research of cancers[1][2][3].
Applications: Cancer-programmed cell death
Formula: C14H15NO4
References: [1]Draoui N, et al. Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux. Mol Cancer Ther. 2014 Jun;13(6):1410-8./[2]Guo C, et al. Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells. Cancer Cell Int. 2019 Jun 28;19:170. /[3]Mohamed F A, et al. Mitochondrial Pyruvate Carrier Inhibition Mitigates Murine Chronic Graft Versus Host Disease By Attenuating the Germinal Center Reaction[J]. Blood, 2023, 142: 459.
CAS Number: 50995-74-9
Molecular Weight: 261.277
Compound Purity: 99.71
Research Area: Cancer
Solubility: DMSO : 33.33 mg/mL (ultrasonic)
Target: Monocarboxylate Transporter
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