BODIPY-Cyclopamine, CAS 334658-24-1

Product Description: BODIPY-Cyclopamine is a fluorescently labeled ligand for the Smoothened (SMO) receptor. The activation of SMO is regulated by Patch protein, and over-activated SMO signaling pathways are associated with tumorigenesis. The NanoBRET (Nanofluorescein bioluminescence resonance energy transfer) technique used in the study can sensitively detect the resonance energy transfer between SMO and BODIPY-Cyclopamine, which can be used for high-throughput screening and kinetic analysis. Studying the binding site of BODIPY-Cyclopamine on SMO can also further explore SMO-targeted drugs[1].

Applications: Cancer-programmed cell death

Formula: C49H70BF2N5O4

References: [1]A NanoBRET-Based Binding Assay for Smoothened Allows Real-time Analysis of Ligand Binding and Distinction of Two Binding Sites for BODIPY-cyclopamine

CAS Number: 334658-24-1

Molecular Weight: 841.92

Research Area: cancer

Target: Smo

• SKU: MEXHY-137115-500UG
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-137115-500UG
• Package Unit: 500 μg
• Quantity Unit: STK