Dibenzylfluorescein, CAS 97744-44-0

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Product Description: Dibenzylfluorescein (DBF) is a fluorogenic probe (Fluoresecent dye) that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19). Dibenzylfluorescein is typically used near its Km value of 0.87-1.9 µM (Ex=485nm，Em=535nm). Dibenzylfluorescein is used to detect changes in CYP catalytic activity caused by drugs or disease[1][2][3][4].

Applications: Metabolism-sugar/lipid metabolism

Formula: C34H24O5

References: [1]Stresser DM., et al. Substrate-dependent modulation of CYP3A4 catalytic activity: Analysis of 27 test compounds with four fluorometric substrates. Drug Metabolism and Disposition 28(12), 1440-1448 (2000). /[2]Donato MT., et al. Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes. Drug Metab. Dispos. 32(7), 699-706 (2004). /[3]Salminen KA, et al. Simple, direct, and informative method for the assessment of CYP2C19 enzyme inactivation kinetics. Drug Metabolism and Disposition 39(3), 412-418 (2011). /[4]Moutinho D, et al. Altered human CYP3A4 activity caused by Antley-Bixler syndrome-related variants of NADPH-cytochrome P450 oxidoreductase measured in a robust in vitro system. Drug Metabolism and Disposition 40(4), 754-760 (2012).

CAS Number: 97744-44-0

Molecular Weight: 512.55

Compound Purity: 99.54

Research Area: Others

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Cytochrome P450;Fluorescent Dye

• SKU: MEXHY-116862-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-116862-5
• Package Unit: 5 mg
• Quantity Unit: STK