Product Description: HKSOX-1 and its derivatives (HKSOX-1r and HKSOX-1m) are novel fluorescent probes designed for highly sensitive and selective detection of the superoxide anion radical (O2•−) in cellular environments. These probes utilize an aryl trifluoromethanesulfonate group that undergoes O2•−-mediated cleavage, releasing a free phenol and emitting fluorescence. They demonstrate excellent specificity and sensitivity across various pH ranges, withstand interference from strong oxidants and reductants typical in cellular contexts. HKSOX-1r, optimized for cellular retention, has been effectively employed in diverse assays including confocal imaging, flow cytometry, and zebrafish embryo studies, highlighting its utility in investigating O2•− roles in inflammation, mitochondrial stress, and other physiological processes[1].
Applications: COVID-19-immunoregulation
Formula: C23H6F10O11S2
References: [1]Fluorescent Probe HKSOX‑1 for Imaging and Detection of Endogenous Superoxide in Live Cells and In Vivo
CAS Number: 1786411-17-3
Molecular Weight: 712.40
Research Area: Inflammation/Immunology
Target: Fluorescent Dye
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