Methoxy-X04, CAS 863918-78-9

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Product Description: Methoxy-X04 is a fluorescent dye that crosses the blood-brain barrier and selectively binds to beta-pleated sheets found in dense core amyloid Aβ plaques. Methoxy-X04 retains in vitro binding affinity for amyloid b (Ab) fibrils (Ki= 26.8 nM). Methoxy-X04 is fluorescent and stains plaques, tangles, and cerebrovascular amyloid in postmortem sections of AD brain with good specificity[1][2].

Applications: Neuroscience-Neurodegeneration

Formula: C23H20O3

References: [1]Bisht K, et al. Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques. J Vis Exp. 2016 Jun 1;(112):54060./[2]Klunk WE, et al. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropathol Exp Neurol. 2002 Sep;61(9):797-805.

CAS Number: 863918-78-9

Molecular Weight: 344.40

Compound Purity: 98.47

Research Area: Others

Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 80°C)

Target: Amyloid-β

• SKU: MEXHY-103240-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-103240-10.1
• Package Unit: 10mM/1mL
• Quantity Unit: STK