Product Description: PARPi-FL is a small molecule and fluorescent inhibitor of PARP1. PARPi-FL is a highly selective probe and can be used as an imaging agent to detect glioblastomas in vivo. (Excitation/Emission max 507/525 nm)[1][3].
Applications: Cancer-programmed cell death
Formula: C34H32BF3N6O3
References: [1]Ziadeh T, et al. Poly(ADP-ribose) polymerase inhibitors in prostate cancer: a cornerstone in precision oncology. Pharmacogenomics. 2021 Dec;22(18):1237-1250./[2]Irwin CP, et al. PARPi-FL--a fluorescent PARP1 inhibitor for glioblastoma imaging. Neoplasia. 2014 May;16(5):432-40. doi: 10.1016/j.neo.2014.05.005. Epub 2014 Jun 23./[3]Susanne Kossatz, et al.Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent. Sci Rep. 2016; 6: 21371.