VPS34-IN-19, CAS 1383716-46-8

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 1-[[4'-(cyclopropylmethyl)-2-(4-pyridinylamino)[4,5'-bipyrimidin]-2'-yl]amino]-2-methyl-2-propanol

Purity: ≥98%

Formula Markup: C21H25N7O

Formula Weight: 391.5

CAS Number: 1383716-46-8

Notes: An inhibitor of VPS34 (IC50 = 15 nM); selective for VPS34 over PI3Kδ (IC50 = 802 nM) and PI3Kα, PI3Kβ, and PI3Kγ (IC50s = >802 nM for all); increases intratumoral levels of LC3-II, a marker of autophagy but does not reduce tumor volume in an RKO colon cancer mouse xenograft model at 50 mg/kg twice per day; reduces SARS-CoV-2 viral titers in isolated human lung tissue at 2.5 and 5 µM

• SKU: CAY41357-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41357-100
• Package Unit: 100 mg
• Quantity Unit: STK