CRISPR

CRISPR

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) are segments of short, regularly placed palindromic nucleotide repetitions. CAS (CRISPR-Associated Protein) is a CRISPR-associated nuclease enabling controlled DNA cleavage.

CRISPR/Cas9 systems allow for targeted gene editing. Briefly, aCRISPR/Cas9 complex binds to a specific DNA sequence, cuts it out and replaces the original sequence with a new sequence. Guide RNA (gRNA) helps to navigate the CRISPR/Cas9 complex in order to target only the specific sequence.

CRISPR/Cas9 represents a valuable tool in gene editing and becomes even more popular in therapy, especially of cancer and other disease involving genetic defects (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315587/).

Picture: CRISPR/Cas9 induced DNA double-strand break.

Highlights:

  • Double nickase plasmids
  • CRISPR/dCas9 activation plasmids
  • CRISPR/dCas9 lentiviral activation particles
  • CRISPR/Cas9 plasmids
  • HDR plasmids
  • CRE vector
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  1. LDH-A CRISPR Activation Plasmid (r2)
    LDH-A CRISPR Activation Plasmid (r2)
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    Sku SACSC-437361-ACT-2
    Manufact. Skusc-437361-ACT-2
    Packaging Unit20 µg
  2. LDH-A CRISPR Activation Plasmid (r)
    LDH-A CRISPR Activation Plasmid (r)
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    Sku SACSC-437361-ACT
    Manufact. Skusc-437361-ACT
    Packaging Unit20 µg
  3. LDH-A CRISPR/Cas9 KO Plasmid (r)
    LDH-A CRISPR/Cas9 KO Plasmid (r)
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    Sku SACSC-437361
    Manufact. Skusc-437361
    Packaging Unit20 µg
  4. WTAP CRISPR Activation Plasmid (bovine2)
    WTAP CRISPR Activation Plasmid (bovine2)
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    Sku SACSC-437360-ACT-2
    Manufact. Skusc-437360-ACT-2
    Packaging Unit20 µg
  5. WTAP CRISPR Activation Plasmid (bovine)
    WTAP CRISPR Activation Plasmid (bovine)
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    Sku SACSC-437360-ACT
    Manufact. Skusc-437360-ACT
    Packaging Unit20 µg
  6. WTAP CRISPR/Cas9 KO Plasmid (bovine)
    WTAP CRISPR/Cas9 KO Plasmid (bovine)
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    Sku SACSC-437360
    Manufact. Skusc-437360
    Packaging Unit20 µg
  7. METTL3 CRISPR Activation Plasmid (bovine2)
    METTL3 CRISPR Activation Plasmid (bovine2)
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    Sku SACSC-437359-ACT-2
    Manufact. Skusc-437359-ACT-2
    Packaging Unit20 µg
  8. METTL3 CRISPR Activation Plasmid (bovine)
    METTL3 CRISPR Activation Plasmid (bovine)
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    Sku SACSC-437359-ACT
    Manufact. Skusc-437359-ACT
    Packaging Unit20 µg
  9. METTL3 CRISPR/Cas9 KO Plasmid (bovine)
    METTL3 CRISPR/Cas9 KO Plasmid (bovine)
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    Sku SACSC-437359
    Manufact. Skusc-437359
    Packaging Unit20 µg
  10. Doublecortin CRISPR Activation Plasmid (r2)
    Doublecortin CRISPR Activation Plasmid (r2)
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    Sku SACSC-437358-ACT-2
    Manufact. Skusc-437358-ACT-2
    Packaging Unit20 µg
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113822 items

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