Shelf life (days): 730.0
Formulation: A solution in acetonitrile
Formal Name: (5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenoic-5,6,8,9,11,12,14,15-d8 acid, (1S)-1-(hydroxymethyl)-2-[(1-oxooctadecyl)oxy]ethyl ester
Purity: ≥99% deuterated forms (d1-d8)
Formula Markup: C41H64D8O5
Formula Weight: 653.1
CAS Number: 2692624-31-8
Notes: 1-Stearoyl-2-arachidonoyl-d8-sn-glycerol (SAG-d8) is intended for use as an internal standard for the quantification of SAG (Item No. 10008650) by GC- or LC-MS. Many protein kinase C (PKC) isoforms require activation via second messengers including Ca2+, diacylglycerol (DAG), and/or a phospholipid in order to phosphorylate target proteins, initiating a variety of important signaling cascades.{943} 1-Stearoyl-2-arachidonoyl-sn-glycerol (SAG) is a DAG that contains the ω-6 polyunsaturated fatty acid arachidonic acid in the sn-2 position and stearic acid in the sn-1 position of the glycerol backbone. It can potently activate PKCα, ε, and δ at nM concentrations.{15530} Independent of PKC signaling, SAG competitively binds to the Ras activator RasGRP with a Ki value of 4.49 µM in Jurkat T cells.{15529}
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