Shelf life (days): 730.0
Formulation: A solution in methyl acetate
Formal Name: 9a-hydroxy-11-oxo-prosta-5Z,12E,14E-trien-1-oic-17,17,18,18,19,19,20,20,20-d9 acid
Purity: ≥99% deuterated forms (d1-d9)
Formula Markup: C20H21D9O4
Formula Weight: 343.5
CAS Number: 2738376-68-4
Notes: 15-deoxy-Δ12,14-Prostaglandin D2 (15-deoxy-Δ12,14-PGD2-d9) is intended for use as an internal standard for the quantification of 15-deoxy-Δ12,14-PGD2 (Item No. 12700) by GC- or LC-MS. 15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2 (Item No. 12010).{11797} It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki = 50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50 = 8 nM).{11399,11055} It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 µM.{11797} 15-deoxy-Δ12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC50 = 0.3 µg/ml).{1424} It inhibits ADP-induced platelet aggregation (IC50 = 320 ng/ml) less potently than PGD2.{1139}
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