Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (S)-2-(amino-15N)-3-(3-bromo-4-hydroxyphenyl-1,2,3,4,5,6-13C6)propanoic-1,2,3-13C3 acid, 2,2,2-trifluoroacetic acid
Purity: ≥98%
Formula Markup: [13C9]H10Br[15N]O3 / CF3COOH
Formula Weight: 384.0
Notes: 3-Bromotyrosine-13C9,15N is intended for use as an internal standard for the quantification of 3-bromotyrosine (Item No. 22606) by GC- or LC-MS.{39012,39010} 3-Bromotyrosine is a product of protein oxidation found after activation of eosinophils during an allergic response.{39007,39008,39010} It has been used as a marker of eosinophil peroxidase-induced protein oxidation in vitro and in vivo.{39008,39011} In addition to its production in eosinophils, 3-bromotyrosine is found at 5-fold higher levels in peritoneal exudate from mice infected with K. pneumoniae compared with uninfected animals, suggesting neutrophils release higher levels of oxidized products during inflammation.{39012} In a human study, 3-bromotyrosine was increased in allergen-challenged lung samples from subjects with allergen-induced asthma.
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