Shelf life (days): 1460.0
Formulation: A lyophilized powder
Formal Name: N5-((2R)-1-((carboxymethyl)amino)-3-(((3S)-5-hydroxy-2-(pentyl-5,5,5-d3)tetrahydrofuran-3-yl)thio)-1-oxopropan-2-yl)-D-glutamine
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C19H30D3N3O8S
Formula Weight: 466.6
Notes: 4-hydroxy Nonenal Glutathione-d3 (4-HNE-GSH-d3) is intended for use as an internal standard for the quantification of 4-HNE-GSH by GC- or LC-MS. 4-hydroxy-Nonenal (4-HNE) is a major aldehyde produced during the lipid peroxidation of ω-6 polyunsaturated fatty acids, such as arachidonic acid and linoleic acid.{869,1103} 4-HNE-GSH is a major adduct formed by the reaction of 4-HNE with GSH.{18611,7334,18610,18731} 4-HNE-GSH levels in liver, plasma, or isolated cells can serve as biomarkers for oxidative stress.{18729} The trapping of 4-HNE by glutathione to give HNE-GSH prevents the formation of DNA adducts with 4-HNE.{1670,18730} In human polymorphonuclear leukocytes, HNE-GSH is metabolized to 1,4-dihydroxynonene glutathione (DHN-GSH), 4-hydroxynonenoic acid glutathione (HNA-GSH), and 4-hydroxy nonenal mercapturic acid (HNE-MA).{18611}
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