Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 5-fluoro-2,4(1H,3H)-pyrimidinedione-2-13C-1,3-15N2
Purity: ≥95%
Formula Markup: C3[13C]H3F[15N2]O2
Formula Weight: 133.1
CAS Number: 1189423-58-2
Notes: 5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-fluorouracil (5-FU; (Item No. 14416) by GC- or LC-MS. 5-FU is a prodrug form of the thymidylate synthase inhibitor fluorodeoxyuridylate (FdUMP).{61376} It is also converted to the active metabolites FUTP and FdUTP, which induce RNA and DNA damage, respectively. In vivo, 5-FU (15 mg/kg) when administered in combination with docetaxel (Item No. 11637) reduces tumor growth in B88 and CAL 27 oral squamous cell carcinoma (OSCC) mouse xenograft models.{61377} Formulations containing 5-FU have been used in the treatment of colorectal, breast, gastric, and pancreatic cancers.
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