Shelf life (days): 730.0
Formulation: A solution in ethanol
Formal Name: (±)8(9)-epoxy-5Z,8Z,14Z-eicosatrienoic-16,16,17,17,18,18,19,19,20,20,20-d11 acid
Purity: ≥99% deuterated forms (d1-d11)
Formula Markup: C20H21D11O3
Formula Weight: 331.5
Notes: (±)8(9)-EET-d11 is intended for use as an internal standard for the quantification of (±)8(9)-EET (Item No. 50351) by GC- or LC-MS. (±)8(9)-EET is a racemic mixture of the R/S enantiomeric forms biosynthesized from arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607).{463,729} (±)8(9)-EET is a major cytochrome P450 (CYP) metabolite in the renal cortex.{1116} It activates PPARα in HEK293 cells when used at a concentration of 1 µM but inhibits NF-κB activity induced by IL-1β in a PPARα-dependent and -independent fashion.{42155} It is also a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 µM.{34481} (8S,9R)-EET (1 µg/kg), but not (8R,9S)-EET, reduces the glomerular filtration rate (GFR) through COX-dependent pre-glomerular vasoconstriction in rats.{1111}
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