Shelf life (days): 730.0
Formulation: A solution in methanol
Formal Name: 9-oxo-11a,15S-dihydroxy-(8ß)-prosta-5Z,13E-dien-1-oic-3,3,4,4-d4 acid
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C20H28D4O5
Formula Weight: 356.5
Notes: 8-iso Prostaglandin E2-d4 (8-iso PGE2-d4) is intended for use as an internal standard for the quantification of 8-iso PGE2 (Item No. 14350) by GC- or LC-mass spectrometry. 8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation.{1943} It is a potent renal vasoconstrictor in the rat.{1943,5157} 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 µM, respectively.{1258} When infused into the renal artery of the rat at a concentration of 4 mg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure.{1943}
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