Shelf life (days): 1460.0
Formulation: A solid
Formal Name: P-[[2-(6-amino-9H-purin-9-yl)ethoxy-1,1,2,2-d4]methyl]-phosphonic acid
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C8H8D4N5O4P
Formula Weight: 277.210181
CAS Number: 1190021-70-5
Notes: Adefovir-d4 is intended for use as an internal standard for the quantification of adefovir (Item No. 18650) by GC- or LC-MS. Adefovir is an active metabolite of the antiviral nucleoside analog adefovir dipivoxil (Item No. 28373).{56174} Adefovir is formed from adefovir dipivoxil by gastrointestinal carboxylesterase 2 (CES2).{56175} It inhibits cytopathogenicity induced by herpes simplex virus 1 (HSV-1) and HSV-2 (EC50 = 7 µg/ml for both in E6SM cells), HIV-1 and HIV-2 (EC50s = 1.8 and 2.5 µg/ml, respectively, in CEM cells), and varicella zoster virus (VZV; EC50 = 10 µg/ml in human embryonic lung fibroblasts).{56176} Adefovir (50 mg/kg, p.o.) reduces increases in lymph node viral DNA and serum IgG levels in a mouse model of AIDS induced by infection with the retroviral complex LP-BM5.{56177} It also inhibits tumor growth induced by Moloney sarcoma virus (MSV) infection in mice at the same dose.{56178}
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