AHU377, CAS 149709-62-6

Shelf life (days): 365.0

Formulation: A solution in ethanol

Formal Name: (aR,?S)-?-[(3-carboxy-1-oxopropyl)amino]-a-methyl-[1,1'-biphenyl]-4-pentanoic acid, a-ethyl ester

Purity: ≥98%

Formula Markup: C24H29NO5

Formula Weight: 411.4908

CAS Number: 149709-62-6

Notes: AHU377 is an ethyl ester prodrug from of the neprilysin inhibitor LBQ657 (Item No. 19829).{42277} It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in anesthetized rats. Formulations containing AHU377 in combination with valsartan have been used in the treatment of mild to moderate hypertension and chronic heart failure.

• SKU: CAY36260-250
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36260-250
• Package Unit: 250 mg
• Quantity Unit: STK
• Application: Reinstoffe