Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (aS,?S,dS,?S)-d-amino-N-(3-amino-2,2-di(methyl-d3)-3-oxopropyl)-?-hydroxy-4-methoxy-3-(3-methoxypropoxy)-a,?-bis(1-methylethyl)-benzeneoctanamide, 2E-butenedioate (2:1)
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C30H47D6N3O6 / 1/2C4H4O4
Formula Weight: 615.8
Notes: Aliskiren-d6 is intended for use as an internal standard for the quantification of aliskiren (Item No. 19640) by GC- or LC-MS. Aliskiren is a nonpeptide inhibitor of renin (IC50 = 0.6 nM for the human enzyme).{31535} Aliskiren (10 and 30 mg/kg per day) reduces blood pressure and prevents albuminuria in renin-overexpressing TG(mRen-2)27 rats in a model of streptozotocin-induced diabetes.{61205} It also reduces cardiac hypertrophy and fibrosis induced by heart pressure overload in mice.{61206} Formulations containing aliskiren have been used in the treatment of hypertension.
English
Deutsch
