Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[2-[(1S)-1-[3-(ethoxy-1,1,2,2,2-d5)-4-methoxyphenyl]-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-acetamide
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C22H19D5N2O7S
Formula Weight: 465.5
CAS Number: 1258597-47-5
Notes: Apremilast-d5 is intended for use as an internal standard for the quantification of apremilast (Item No. 18502) by GC- or LC-MS. Apremilast is an inhibitor of phosphodiesterase 4 (PDE4) with an IC50 value of 74 nM when tested in U937 cell lysates with 1 mM cAMP.{29958,29960} It is orally active, significantly decreasing epidermal thickness and the epithelial cell proliferation index in a mouse model of psoriasis.{29960} Apremilast reduces both TNF-α and matrix metalloproteinase-3 production in gut lamina propria mononuclear cells from patients with inflammatory bowel disease.{29957} It also blocks spontaneous production of TNF-α from human rheumatoid synovial cells and improves the clinical score in mouse models of arthritis.{29959}
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