Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (1R,2S,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[[1,1-di(methyl-d3)ethyl-2,2,2-d3]amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
Purity: ≥99% deuterated forms (d1-d9)
Formula Markup: C27H36D9N5O5
Formula Weight: 528.73144
CAS Number: 1256751-11-7
Notes: Boceprevir-d9 is intended for use as an internal standard for the quantification of boceprevir (Item No. 18379) by GC- or LC-MS. Boceprevir is an inhibitor of hepatitis C virus (HCV) non-structural protease 3/4A (NS3/4A; Ki = 14 nM for the HCV genotype 1b enzyme).{30614} Boceprevir inhibits HCV replication in Huh7 cells (EC50 = 200 nM).{36164} It also inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro; Ki = 1.8 µM) and reduces cytopathic effects of SARS-CoV-2 in Vero cells (EC50 = 1.31 µM).{58053} Formulations containing boceprevir have been used in the treatment of HCV.
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