Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (1S)-1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl-2,3,5,6-d4)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C24H21D4FO5S
Formula Weight: 448.540943
CAS Number: 1997338-61-0
Notes: Canagliflozin-d4 is intended for use as an internal standard for the quantification of canagliflozin (Item No. 11575) by GC- or LC-MS. Canagliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC50 = 2.2 nM) that less potently blocks SGLT1 (IC50 = 910 nM).{18745} Canagliflozin is orally bioavailable and lowers plasma glucose by lowering the renal threshold for glucose and increasing urinary glucose excretion in animals.{18745,33510} Formulations containing SGLT2 inhibitors, including canagliflozin, have been used to treat type 2 diabetes mellitus.{33509}
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